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Alzheimer’s Disease (AD) is a debilitating neurodegenerative disorder with no known cure. The increasing prevalence of AD presents a significant challenge. Scientists are researching advanced treatment methods through the exploration of both natural and synthetic alternatives. 

Numerous clinical trials have highlighted the potential effectiveness of serotonergic psychedelics, such as LSD, DMT, and psilocybin, in treating Alzheimer’s disease. For additional intriguing information, you are invited to explore online resources or consider “purchasing psychedelics online in Canada.”

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The Significance of Psychedelics in Alzheimer’s Treatment

Conventional psychedelics demonstrate potential in treating early-stage Alzheimer’s Disease (AD) or mild cognitive impairment (MCI) by stimulating the growth of brain cells.

Psychedelics may enhance neural plasticity for learning and memory by targeting specific brain receptors. This could potentially slow or even reverse the neurodegenerative effects of AD. In addition, psychedelics may help alleviate depression and anxiety, which are often experienced by AD patients, by inducing positive psychological responses.

There are still uncertainties about how psychedelic treatments work. Some suggest that the intense effects of high-dose psychedelics, such as mystical experiences or feelings of self-dissolution, are vital for obtaining psychological benefits. Others argue that the key lies in the biological changes triggered by these substances. Both viewpoints may have merit.

Conventional psychedelics appear to aid the brain in adapting and reducing inflammation, even at lower doses. Therefore, low-dose treatments might be beneficial for conditions like brain degeneration or migraines without significant mind-altering effects. However, for depression, anxiety, or addiction, the mind-altering effects seem essential, leading to introspection and changes in behavior. As a result, both low and high doses should be considered for personalized therapy.

The Impact of Serotonergic Psychedelics

Serotonergic psychedelics, which include LSD (lysergic acid diethylamide), DMT (dimethyltryptamine), and psilocybin (found in magic mushrooms), are garnering attention.

Psychedelics are gaining attention due to their potential therapeutic impact on a variety of mental health conditions.

conditions. 

Many experts point to serotonin receptors, noted for their ability to boost cognition and regulate neuroplasticity, as a hopeful area of emphasis in Alzheimer’s Disease (AD) research. 

These compounds primarily exert their pharmacological effects by modifying the serotonin system in the brain, leading to alterations in perception, mood, and consciousness. A number of studies support this theory, as outlined below:

  • In particular, the 5-HT2A subtype of the receptors affects the gene expression of neurotrophins that enhance neuroplasticity in brain areas impacted by AD. 
  • These receptors help manage cortical signalling, vital for cognition, memory, and synaptic plasticity. 
  • Despite their atypical distribution within neurons, serotonin receptors play a role in neural development, regeneration, and plasticity.

Significant Research Findings

  • Serotonergic psychedelics have shown potential in reducing aspects of AD pathology by promoting neuroplasticity.
  • Traditional psychedelics impact neurotransmission, promote synaptic restructuring, and increase factors contributing to neuronal survival.
  • Certain psychedelics, such as muscimol and Sig-1R agonists, might reduce the neurotoxicity associated with the progression of AD.
  • Traditional psychedelics activate pathways in brain areas affected by AD, indicating a potential for slowing down or reversing brain deterioration.
  • Psilocybin mushrooms catalyze neural plasticity to stimulate neurogenesis and induce lasting alterations in brain circuits.
  • Psychedelics improve brain connectivity by targeting receptor genes and triggering changes in neurons and networks.

Clinical studies suggest that both traditional and non-traditional psychedelics derived from magic mushrooms affect various biological processes in the brain. These impacts include rapid changes in gene expression and significant modifications in brain structure and function.

These psychedelics interact with receptors such as serotonin, sigma, NMDA, and GABA, which leads to improved synaptic plasticity and brain rejuvenation. As a result, psychedelics could potentially enhance behaviour, memory, and cognition, positioning them as promising therapeutic agents for treating AD and similar disorders.

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  1. LSD

LSD is a synthetic drug derived from a fungus called ergot, which is found on rye grains. This psychoactive compound can transform perceptions, emotions, and thoughts, even in small quantities.

Overuse of LSD can lead to intense hallucinations and distortions of time and space. Be cautious, as substances sold as LSD might be other drugs such as NBOMe or members of the 2C drug family. 

ProductKittease – Ketamine Microdose Troche (30x50mg)Zenly – LSD Gel Tabs – 600ug (100ug Per Tab)Zenly – LSD Gummies – Sour Zen Berry – 200ug (100ug Per Gummy)
Intended UseStress, depression, pain management, PTSD, OCD, work-related stress, performance anxiety, insomnia, and addiction.Unique experiencesUnique experiences
Dosage50mg per troche / 30 per pack – 1.5 grams of ketamine/ per pack600ug total/6 Tabs (100ug/Tab)200ug total/2 Gummies (100ug/Gummy)
Usage GuidelinesTake one full trocheConsume one complete tab for the full effect. Wait at least 2 hours before taking another.Consume one complete gummy for the full effect. Wait at least 2 hours before taking another.
BenefitsRapid onset with low risk, enhanced receptivity, ideal for self-reflection and cognitive improvement.Accurately measured dose for the perfect trip, lab-verifiedAccurately measured dose for the perfect trip, lab-verified
  1. Magic Mushrooms

There are over 180 mushroom species recognized for their therapeutic benefits and positive influence due to their content of psilocybin and psilocin.

on mental health. 

The impact may vary depending on the type of mushroom, the specific cultivation batch, the amount consumed, and the person’s individual tolerance. While some people opt for microdosing to experience subtle effects, others take larger doses for a more intense journey. Additionally, the quality can differ, hinging on the cultivation techniques.

Blue Meanies, scientifically known as Panaeolus cyanescens, are small dried fungi that flourish in warm, tropical climates, typically growing on cow and water buffalo dung. They display blue spots on their surface as they age, giving rise to their name.

  • These fungi are rich in psilocybin and psilocin, with high concentrations. 
  • They have a history of use for recreational purposes, especially among the Balinese people, who consume them during celebrations and for artistic inspiration.
  • Due to their hallucinogenic properties, they are popular among tourists and travelers in Bali and similar places. These effects can include feelings of euphoria, hallucinations, happiness, and uncontrollable laughter.
  1. DMT

DMT, a potent hallucinogenic compound, is found in certain plants such as Psychotria viridis and Chacruna. Often called the “spirit molecule,” these controlled substances can trigger deep psychedelic experiences. They offer a brief but intensely immersive journey characterized by vivid visual and auditory hallucinations. 

ProductDream Machine – Vape Cartridge – DMT 1mlIntegral Alchemist – ACACIA Changa Pre-RollIntegral Alchemist – Mimosa- 1ml DMT Vape Cart
DescriptionExplore hyperdimensional realms with DMT.Experience ayahuasca-like effects with a blend of herbs and DMT.Embark on an odyssey of mystical visions and spiritual revelations with DMT.
DMT Content1gApproximately 90mg1ml
InstructionsPreheat the cartridge and inhale Enjoy the pre-roll at a pace that suits you best.Breathe in the vapor for instant effects.
EffectsIntense hallucinations, altered state of awareness.Vivid psychedelic voyage, prolonged duration.Spiritual awakening, bliss, significant changes in viewpoint.
DurationVaries from person to personCan last up to an hourMay last up to 30 minutes

Long-Term Effects of Psychedelic Use

Current research is geared towards understanding the long-term implications of using psychoactive substances. Although this field of knowledge is still expanding, “long-term effects” generally refers to any lasting changes in cognition, emotions, or memory following extended use of psychedelics.

The study of long-term effects of psychedelics is complex. Some studies point towards potential mental health benefits, while others indicate possible risks, including the onset of psychosis.

Despite these complexities, researchers are persistently working to understand the potential impacts of long-term psychedelic use on mental health. They are carrying out rigorous research and tracking individuals over long periods to collect more accurate data.

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Studies suggest a significant change in Alzheimer’s disease treatment, indicating that psychedelics could revolutionize how we tackle brain disorders. Experts propose that therapeutic use of these substances may entirely reshape Alzheimer’s treatment, offering renewed optimism for numerous patients and their families.

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Frequently Asked Questions

How do psychedelics differ from other substances typically used in Alzheimer’s treatments?

Psychedelics distinguish themselves from traditional Alzheimer’s medications due to their unique therapeutic approach and effects. By targeting the brain’s serotonin system, they stimulate new neural connections and facilitate profound psychological experiences that foster emotional well-being.

Unlike conventional drugs that primarily manage symptoms, psychedelics are being assessed by Health Canada for their long-lasting benefits and holistic treatment approach, which includes therapy.

Research into the use

The potential of psilocybin to treat conditions like obsessive-compulsive disorder and its safety record in preventing multi-organ failure distinguishes it from conventional controlled substances.

Can psychedelic-assisted therapy be a viable treatment for Alzheimer’s patients facing end-of-life distress?

Psychedelic-assisted therapy could be advantageous for Alzheimer’s patients who are critically ill and dealing with the approaching end of their lives.

  • It offers emotional relief. This therapy has shown to mitigate feelings of anxiety and depression in certain individuals, especially those who are gravely ill. This relief could potentially extend to Alzheimer’s patients as well.
  • Generally safe when supervised. When given in a controlled setting under the supervision of a professional therapist, the usage of psychedelics is typically harmless and is well accepted by most people.
  • Can potentially improve quality of life. For an Alzheimer’s patient, an emotional uplift can be hugely beneficial, even if it doesn’t enhance memory capabilities.
  • Further research is required. Although this therapy seems promising, additional investigations are needed to affirm its safety and effectiveness for Alzheimer’s patients, particularly those nearing life’s end.

How long does a psychedelic therapy session for Alzheimer’s patients last?

  1. Preparation Stage. This stage involves one or two sessions, each running between 1 to 2 hours. These sessions aim to ready the patient for the forthcoming experience, establish expectations, and build trust with the therapist.
  2. Primary Psychedelic Session. This key session, where the patient consumes the psychedelic drug, generally spans 4 to 6 hours. The patient spends this duration in a monitored setting, often lying down with eye shades on and listening to music, under the therapist’s careful supervision.
  3. Integration Stage. After the session, follow-up appointments are held to help the patient interpret and integrate their experience. These appointments usually last 1 to 2 hours each, with the number of sessions differing.

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